Alternative splicing of CD19 mRNA in pediatric leukemia and CART-19 therapy resistance-regulators, genetic variants, and cryptic isoforms

Funding period:

01.11.2021 - 31.10.2024

Project description:

The project will combine high-throughput experiments, bioinformatics analysis and mathematical modeling to derive a molecular understanding of CART19 therapy resistance. This will derive prognostic biomarkers and targets of combination therapy.

Project coordination

Stefan Legewie

Prof. Dr.

Member of the SRCSB Board of Directors

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