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SpliceCD19

Alternative splicing of CD19 mRNA in pediatric leukemia and CART-19 therapy resistance-regulators, genetic variants, and cryptic isoforms

Funding period:: 01.11.2021 - 31.10.2024
Project description:: The project will combine high-throughput experiments, bioinformatics analysis and mathematical modeling to derive a molecular understanding of CART19 therapy resistance. This will derive prognostic biomarkers and targets of combination therapy.