- Funding Period:
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2007 – 2010
- Project description:
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PSYSMO is an international, interdisciplinary effort that integrates functional genomics, bioinformatics and mathematical modeling to develop a systems understanding of a key microbe that serves as a paradigm of metabolically versatile soil bacteria that offer considerable potential for biotechnological applications. The long term goal of the effort will be to link systems biology with synthetic ciology, through cellular re-programming, the in silico reproduction of metabolic sub-entities of industrial importance, the prediction of their behaviour in response to process-relevant internal (e.g. hyperproduction of metabolites/enzymes/polymers) and external (solvent, solute stress) perturbations, and systems-based experimental interventions to achieve quantum increases in process performance in a range of biotechnological applications.
- Partner:
- K. Timmis
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Helmholtz Centre for Infection Research (DE)
- V. Martins dos Santos
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Helmholtz Centre for Infection Research (DE)
- K.-E. Jaeger
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University Düsseldorf (DE)
- B. Tümmler
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Medical School Hannover (DE)
- D. Jahn, D. Schomburg
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TU Braunschweig (DE)
- M. Reuss
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University Stuttgart Center Systems Biology (DE)
- A. Schmid
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University Dortmund (DE)
- A. Kremling
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Max-Planck Institute Magdeburg (DE)
- H. Westerhoff
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University Manchester (UK)
- E. Pistikopoulos
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Imperial College London (UK)
- T. McGenity
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University Essex (UK)
- V. de Lorenzo
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CSIC-CNB Madrid (ES)
- A. Valencia
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CNIO Madrid (ES)
- E. Diaz
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CSIC Madrid (ES)
- CSIC-IboCAT Madrid
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CSIC-IboCAT Madrid (ES)
- CSIC Granada
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CSIC Granada (ES)