Position within the page tree

Melanoma Sensitivity

Despite remarkable efforts, metastatic melanoma still presents with significant mortality.

Project description:: By combining statistical and network modeling and systems analysis with basic research and clinical data we aim to elucidate mechanisms of therapy-resistance of melanoma and to identify combinatorial systems biomarkers to prognosticate treatment responsiveness of BRAF mutated metastatic melanoma to BRAF (dabrafenib) / MEK (trametenib) inhibitors and to TRAIL death receptor agonists.