Novel players in chromatin
Post-translational modifications of histones and DNA define
distinct chromatin or “epigenetic” states. The set of characterised
histone modifications is far from complete and many modifications
are awaiting identification and functional characterisation.
Additionally, for many modifications it is still unclear how they act
and how distinct “epigenetic” (or transcriptional) states are
inherited through cellular divisions.
We are aiming i) to identify novel players in chromatin (in
particular histone and RNA modifications) and to crack how they
(mechanistically) regulate chromatin function, ii) to unravel how
chromatin states can mediate “epigenetic” (or transcriptional)
memory through cell divisions as well as iii) to understand how
cellular metabolism impacts on chromatin architecture and hence
transcription. For this we are applying a combination of chromatin
biochemistry, different “omics” techniques, and single cell
approaches as well as mathematical modelling in mouse models,
mESCs and also yeast cells.
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